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In total, 31 have been published by pirbright.ac.uk which Ground News has aggregated in the past 3 months.

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Top pirbright.ac.uk News

Vaccines

New Study Brings Vaccine Hopes for Zoonotic Nipah Virus, Which Is Deadly to Pigs

100% Center coverage: 1 sources

Scientists at The Pirbright Institute have taken a major step forward in tackling one of the world's most dangerous viruses, the Nipah virus, by evaluating vaccine candidates for pigs.See the Story

Nipah Virus

Megabodies Expand the Nanobody Toolkit for Protein Structure Determination by Single-Particle Cryo-EM

100% Center coverage: 1 sources

Nanobodies are popular and versatile tools for structural biology. They have a compact single immunoglobulin domain organization, bind target proteins with high affinities while reducing their conformational heterogeneity and stabilize multi-protein complexes. Here we demonstrate that engineered nanobodies can also help overcome two major obstacles that limit the resolution of single-particle cryo-electron microscopy reconstructions: particle si…See the Story

Nottingham, England · Nottingham

'Vivaldi': an amplicon-based whole-genome sequencing method for the four seasonal human coronaviruses, 229E, NL63, OC43 and HKU1, alongside SARS-CoV-2

'Vivaldi': an amplicon-based whole-genome sequencing method for the four seasonal human coronaviruses, 229E, NL63, OC43 and HKU1, alongside SARS-CoV-2 Prior to the emergence of SARS-CoV-2 in 2019, alphacoronaviruses 229E and NL63 and betacoronaviruses OC43 and HKU1 were already established endemic 'common cold' viral infections. Despite their collective contribution towards global respiratory morbidity and mortality and potential to inform the f…Read Article

Membrane Expression Enhances Folding, Multimeric Structure Formation, and Immunogenicity of Viral Capsid Proteins

Membrane Expression Enhances Folding, Multimeric Structure Formation, and Immunogenicity of Viral Capsid Proteins Viral capsid proteins are widely explored for subunit vaccine development but are often hampered by their complexity of production and low immunogenicity. Here, we report a simple approach to overcoming these challenges by combining mRNA vaccine technology with protein engineering. Using African swine fever virus (ASFV) capsid protei…Woking · Woking Read Article

Understanding the mechanisms of mitochondrial rewiring during viral infections

Understanding the mechanisms of mitochondrial rewiring during viral infections As intracellular parasites, viruses must hijack and often rewire organelles, signalling pathways and the bioenergetics machinery of the infected cell to replicate their genome, produce viral proteins and assemble new viral particles. Mitochondria are key eukaryotic organelles often referred to as the cell's powerhouse. They control many fundamental cellular processes,…Pirbright · Pirbright Read Article

Foot-and-Mouth Disease: The Gaps in South Africa's Efforts to Keep It Under Control

Coverage: 5 sources

In mid August, South Africa's minister of agriculture, land reform and rural development Thoko Didiza responded to outbreaks of foot-and-mouth disease with a nationwide ban on the movement of cattle for 21 days. By late August, 127 cases of the disease had been recorded in six of the country's nine provinces. The Conversation Africa spoke with Rebone Moerane and Melvyn Quan about the disease, its effects and the government's mitigation strategie…Trade · Free State See the Story

Avian Influenza Fear Sonora in Arizona

The slaughter of more than 5 million birds keeps producers concerned, said the holder of SAGARHPA, Célida López Cárdenas. Enrique Delgadillo/La Onda 99.5 FM and 1190 AM PHOENIX — At the recent summit of the Arizona-Mexico Commission, many issues were put on the table, among them, the situation that keeps Sonora producers on alert and busy keeping millions of birds healthy in order to prevent the spread of H5N1 avian influenza. Célida López Cárde…Influenza · Sonora See the Story

Bat-specific adaptations in interferon signaling and GBP1 contribute to enhanced antiviral capacity

Bat-specific adaptations in interferon signaling and GBP1 contribute to enhanced antiviral capacity Bats are reservoirs of emerging zoonotic viruses that may cause severe disease in humans and agricultural animals. However, it is poorly understood how bats can tolerate diverse viral infections. Here, we characterized type I interferon response pathways in kidney cell lines derived from two divergent bat species, Pteropus alecto and Eptesicus fus…Pirbright · Pirbright Read Article

A centralised immunogen approach to develop a more broadly protective modified live porcine reproductive and respiratory syndrome virus 1 vaccine candidate

A centralised immunogen approach to develop a more broadly protective modified live porcine reproductive and respiratory syndrome virus 1 vaccine candidate More efficacious vaccines are required to improve control of porcine reproductive and respiratory syndrome viruses (PRRSV). One strategy that has shown promise is the use of centralized antigens, generated from consensus sequence data. Here, we evaluated the consensus sequence approach to dev…Vaccines Read Article

CRISPR chicken cell study boosts potential for vaccine development

Pirbright scientists create gene-edited chicken cells that produce much higher yields of influenza A and Newcastle disease virus – a key to improved vaccine production.CRISPR · Woking See the Story

Clade 2.3.4.4b highly pathogenic avian influenza H5N1 viruses: knowns, unknowns, and challenges

Clade 2.3.4.4b highly pathogenic avian influenza H5N1 viruses: knowns, unknowns, and challenges Since 2020, the clade 2.3.4.4b highly pathogenic avian influenza (HPAI) H5N1 viruses have caused unprecedented outbreaks in wild birds and domestic poultry globally, resulting in significant ecological damage and economic losses due to the disease and enforced stamp-out control. In addition to the avian hosts, the H5N1 viruses have expanded their host…Influenza Read Article

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Top pirbright.ac.uk News

New Study Brings Vaccine Hopes for Zoonotic Nipah Virus, Which Is Deadly to Pigs

Megabodies Expand the Nanobody Toolkit for Protein Structure Determination by Single-Particle Cryo-EM

'Vivaldi': an amplicon-based whole-genome sequencing method for the four seasonal human coronaviruses, 229E, NL63, OC43 and HKU1, alongside SARS-CoV-2

Membrane Expression Enhances Folding, Multimeric Structure Formation, and Immunogenicity of Viral Capsid Proteins

Understanding the mechanisms of mitochondrial rewiring during viral infections

Foot-and-Mouth Disease: The Gaps in South Africa's Efforts to Keep It Under Control

Avian Influenza Fear Sonora in Arizona

Bat-specific adaptations in interferon signaling and GBP1 contribute to enhanced antiviral capacity

A centralised immunogen approach to develop a more broadly protective modified live porcine reproductive and respiratory syndrome virus 1 vaccine candidate

CRISPR chicken cell study boosts potential for vaccine development

Clade 2.3.4.4b highly pathogenic avian influenza H5N1 viruses: knowns, unknowns, and challenges

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Membrane Expression Enhances Folding, Multimeric Structure Formation, and Immunogenicity of Viral Capsid Proteins

Understanding the mechanisms of mitochondrial rewiring during viral infections

Foot-and-Mouth Disease: The Gaps in South Africa's Efforts to Keep It Under Control

Avian Influenza Fear Sonora in Arizona

Bat-specific adaptations in interferon signaling and GBP1 contribute to enhanced antiviral capacity

A centralised immunogen approach to develop a more broadly protective modified live porcine reproductive and respiratory syndrome virus 1 vaccine candidate

CRISPR chicken cell study boosts potential for vaccine development

Clade 2.3.4.4b highly pathogenic avian influenza H5N1 viruses: knowns, unknowns, and challenges