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Top fightaging.org News

Late-Life Mood Disorders May Signal Neurodegenerative Diseases
Alzheimer's Disease

Late-Life Mood Disorders May Signal Neurodegenerative Diseases

100% Center coverage: 3 sources
Depression and bipolar disorder of late onset may represent more than just mental health conditions. Growing evidence suggests these late-life mood disorders (LLMDs) could be not merely risk factors, but rather early warning signs of neurodegenerative diseases like dementia, even when they appear years before memory loss or other cognitive symptoms become apparent.See the Story
New Therapeutic Strategy Designed to Help Lower Cholesterol Levels
Diabetes · Barcelona

New Therapeutic Strategy Designed to Help Lower Cholesterol Levels

100% Center coverage: 2 sources
When the amount of cholesterol in the blood is too high, hypercholesterolemia can develop, causing serious damage to the arteries and cardiovascular health. Now, a study led by the University of Barcelona and the University of Oregon presents a new therapeutic tool capable of regulating blood cholesterol levels and thus opening up new perspectives in the fight against atherosclerosis caused by the accumulation of lipid plaques in the artery wall…See the Story
Gut Microbiome Study Links Parkinson's Disease to Environmental Chemicals
Parkinson's Disease

Gut Microbiome Study Links Parkinson's Disease to Environmental Chemicals

100% Center coverage: 1 sources
Parkinson's disease is a progressive and common neurodegenerative condition, typically characterized by involuntary shaking, stiffness, and slow movement. Beyond these motor symptoms, individuals often experience a range of non-motor issues, including significant gut problems such as constipation, inflammation, and increased intestinal permeability.See the Story

Caveolin-1 Gene Therapy Reduces Cognitive Decline in an Alzheimer's Mouse Model

Researchers here assess a compensatory approach to the neurodegeneration of Alzheimer's disease, meaning an enhancement of the ability of cells to operate in the face of damage rather than addressing the damage itself. This can inevitably only slow progression of the condition, and is not a path to a curative therapy. Nonetheless, tinkering with cell metabolism in order to slow disease progression is arguably the dominant approach to the develop…Alzheimer's DiseaseSee the Story

Is LDL Cholesterol Actually Important to Cardiovascular Risk Across the Whole Population?

Cholesterol attached to LDL particles leaves the liver to be transported in the bloodstream to tissues throughout the body. Along the way, this is expected to contribute to development of atherosclerosis in blood vessel walls via deposition of excessive cholesterol in some locations. Patients with homozygous familial hypercholesterolemia, who exhibit loss of function mutations in the LDL receptor and enormously elevated LDL cholesterol in blood,…Read Article

Fifteen Questions: David Sinclair on Age Reversal, Exercise, and Immortal Yeast Cells

100% Left coverage: 1 sources
The Professor of Genetics sat down with Fifteen Minutes to discuss anti-aging research, the wellness industry, and his grandmother.Wellness · United StatesSee the Story

An Epigenetic Clock For Intrinsic Capacity

Researchers continue to produce a fair number of new aging clocks every year to attempt to measure biological age. One might at this point ask whether the life science community should instead focus on better understanding and utilizing the best of the existing clocks. No new clock can be applied naively to the assessment of potential therapies to slow or reverse aging, as a new clock arrives with no understanding of how exactly the measures mak…Framingham · FraminghamRead Article

Healthcare Must Change as We Become More Capable of Intervening in Aging

The present approach to aging in the healthcare community is uncomfortably close to being a matter of Cnut the Great on the beach telling the tide to go back. In clinical practice most of the major diseases of aging remain irreversible for the average individual, a progression that can only be modestly slowed. The only way to achieve the possibility of turning back these conditions is to repair the forms of accumulated cell and tissue damage tha…United States · United StatesRead Article

A Dose-Response Curve for Physical Activity and Slowed Brain Aging

Studies of the dose-response curve for exercise have typically shown that little exercise is much better than no exercise, and gains continue at a slowing pace up to a fair way above the recommendation of 150 hours of moderate to vigorous physical activity per week. See research showing that two to four times that amount further improves outcomes, for example. At some point, however, diminishing returns tip over into harm. There is such as thing…HealthSee the Story

Fecal Microbiota Transplantation from Young Mice to Old Mice Improves Health

The gut microbiome is made up of thousands of microbial species in various proportions. The balance of populations shifts with age to favor harmful, inflammatory microbes over beneficial microbes that manufacture metabolites necessary to normal tissue function. This contributes to degenerative aging to some degree. One of the few ways to permanently alter the gut microbiome is to transplant fecal matter from one animal to another. Fecal microbio…SpeciesRead Article

Reviewing the Measurement and Treatment of Immune System Aging

With age the immune system becomes (a) ever less capable, but also (b) ever more inflammatory and overactive. Sustained inflammation is disruptive to tissue structure and function, contributing to age-related conditions, while the growing incapacity leads to an inability to sufficiently defend against infectious pathogens, destroy senescent cells, and destroy cancerous cells. The immune system is complex, the regulation of inflammation particula…Read Article

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