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Top fightaging.org News

Obesity

New Campaign Launched to Boost Mental Wellbeing Through Physical Activity in Essex

100% Center coverage: 1 sources

The campaign offers resources and advice on how physical activity can improve mental wellbeing.United States · United States See the Story

An APOE Mutation Inhibits cGAS-STING Signaling to Reduce Inflammation in the Aging Brain

Variants of the APOE gene (the most common labeled as APOE-ε2, APOE-ε3, and APOE-ε4) have been show to alter the risk of developing Alzheimer's disease. Work in recent years has pointed to effects on the behavior of microglia in the aging brain as the important mechanism is driving risk. Bad variants of APOE, predominantly APOE-ε4 in the population at large, lead to greater inflammation driven by activated and dysfunctional microglia. Good varia…Alzheimer's Disease · Christchurch Read Article

HMGB1 is an Important Secreted Factor in Transmission of Cellular Senescence

The signal molecules secreted by senescent cells can encourage other nearby cells to also become senescent. Thus the high burden of lingering senescent cells in aged tissues is both directly harmful to tissue structure and function, but also indirectly harmful by encouraging further growth of that burden of cellular senescence. The research community has investigated which of the many different components of the senescence-associated secretory p…Read Article

It seems like both Neanderthal Y-Chromosome DNA and Mitochondrial DNA originated from interbreeding with Homo Sapiens

100% Center coverage: 1 sources

For the past 40,000 years, Homo sapiens have been the only human species on Earth. Our ancestors, including the Neanderthals and Denisovans, disappeared long before us, leaving behind only fossils and traces in our DNA. But what if these ancient relatives had survived? How would they appear today, and could they live alongside us in modern society? Neanderthals: Strong and Stocky with Unique Features According to Daily Mail, Neanderthals, our cl…Fossils See the Story

A Novel Approach to Thermogenesis Without Involving Uncoupling Protein 1

Mitochondrial uncoupling is the process by which mitochondria in cells switch from producing the chemical energy store molecule adenosine triphosphate (ATP) to releasing that energy as heat. This is of interest in the context of aging because upregulation of mitochondrial uncoupling via a range of strategies appears to somewhat slow aging in animal studies. Sustained upregulation of mitochondrial uncoupling also produces a reduction in fat tissu…ATP Tour · United States Read Article

Inflammatory cGAS-STING Signaling as a Component of Photoaging of Skin

Leakage of DNA fragments from either the nucleus or mitochondria into the cell cytosol is characteristic of a wide range of forms of cell stress, dysfunction, and damage. One component of the innate immune system is that all cells incorporate mechanisms to recognize the presence of inappropriately localized DNA and raise the alert via the secretion of inflammatory signals. This is in part a defense against bacterial and viral infection, but the …United States · United States Read Article

Virus Induced Cellular Senescence as a Cause of Lasting Consequences Following Respiratory Infection

Some forms of respiratory infection can cause lasting issues and loss of function. It has been suspected that an increased burden of senescent cells is one of the mechanisms involved in post-infection effects. While senescent cells are created constantly throughout life, a population of lingering senescent cells grows with age to disrupt tissue structure and function via inflammatory signaling. An increase in this burden of senescent cells is al…Read Article

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Top fightaging.org News

Deaths From Heart Attacks Are Way Down. Here's What's Killing Us Instead

Glycogen Metabolism in Neurons Emerges as Key to Fighting Alzheimer's

How Chinese scientists cracked the secret of organ regeneration

3BTRON: A Blood-Brain Barrier Recognition Network

New Campaign Launched to Boost Mental Wellbeing Through Physical Activity in Essex

An APOE Mutation Inhibits cGAS-STING Signaling to Reduce Inflammation in the Aging Brain

HMGB1 is an Important Secreted Factor in Transmission of Cellular Senescence

It seems like both Neanderthal Y-Chromosome DNA and Mitochondrial DNA originated from interbreeding with Homo Sapiens

A Novel Approach to Thermogenesis Without Involving Uncoupling Protein 1

Inflammatory cGAS-STING Signaling as a Component of Photoaging of Skin

Virus Induced Cellular Senescence as a Cause of Lasting Consequences Following Respiratory Infection

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