Scientists Extend Lifespan by More Than 25% by Switching On a Cellular Energy Sensor
4 Articles
4 Articles
Scientists Extend Lifespan by More Than 25% by Switching On a Cellular Energy Sensor
Direct activation of the cellular energy sensor AMPK extended lifespan in three distantly related model organisms, strengthening the case for testing the approach in mammals. Every cell has to decide how to spend its limited supply of energy. When fuel runs low during fasting, exercise, or other forms of stress, cells can cut back on [...]
Researchers activate AMPK specifically with the active ingredient 991. In the case of flies and worms, the lifespan increases partly by more than 25 percent.
Direct Pharmacological Activation of AMPK Modestly Extends Life in Short-Lived Species
AMPK is the target of a range of interventions known to modestly slow aging in short-lived species. Like much of the complex array of evolved machinery that responds to various forms of cellular stress with improved maintenance, repair of damage, and a consequent slowing of aging, AMPK is involved in the regulation of energy metabolism. Many of these interventions, such as metformin, are far from robust. The animal data is mixed. One might argue…
Researchers at the MRC Laboratory of Medical Sciences, Imperial College London and the University of Cologne have discovered that direct activation of the AMPK cell energy sensor can increase longevity in model organisms,...
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