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MS the CD4-T cell mediated Progression

Multiple Sclerosis

MS the CD4-T cell mediated Progression

Tweet This study looks in EAE and concludes that a CNS resident CD4 T cell subset expressing Hobit inhibits disease. Fingolimod did not inhibit chronic EAE and did not inhibit CD4 T cells in the brain. They then used anti-CD4 and it did not inhibit the chronic bit of EAE either . They then added Nicotinamide adenine dinucleotide (NAD) administration toanti-CD4 and the chronic phase was said to be inhibited….Now I thought how can it raise the dea…Read Article

Using antibodies to target Brain components of Disease fails…Again

Using antibodies to target Brain components of Disease fails…Again

Promoting repair by blocking inhibitors of nerve regeneration has been tried before with anti-NOGO/LINGO-1 and againt here with anti repulsive guidance molecule (RGMa). They gave a shed-load of ant…Read Article

I don’t understand Why

I don’t understand Why

Ask is fingolimod more effective than dimethyl fumarate….and I think the answer would be yes…so here we have a trial of dimethyl fumarate against ponesimod which acts similarly to fingo…Read Article

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