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Tylenol use in pregnancy may be linked with uterus, ovary changes in daughters: Study

Researchers found prenatal acetaminophen exposure was associated with 40% smaller ovarian volume and 23% fewer follicles in baby girls, but not cause and effect.

  • A new study published Wednesday in Human Reproduction Open found girls exposed to acetaminophen in the womb had, on average, 40% smaller ovarian volume, 13% smaller uterine volume, and 23% fewer ovarian follicles.
  • Scientists in Denmark enrolled 685 women during the first trimester of pregnancy, evaluating 302 of their baby girls at 3 months old to assess reproductive development.
  • While noting the findings are "impressive," Dr. Hugh Taylor of the Yale School of Medicine cautioned that the study does not establish acetaminophen exposure causes reproductive organ changes.
  • The American College of Obstetricians and Gynecologists maintains acetaminophen remains the safest medication for pain or fever during pregnancy, advising use only in moderation.
  • Last year, acetaminophen became a political issue when President Donald Trump urged pregnant women to "tough it out" regarding pain, despite established medical consensus supporting the drug's safety.
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The researchers emphasized that this was an observational study and that the results do not prove a causal relationship.

·Ljubljana, Slovenia
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Far Right

Paracetamol is considered to be the pain and fever agent to which pregnant women are allowed to resort if other preparations are more problematic. A new Danish human study is now questioning this routine: In three-month-old girls whose mothers had taken the medicine during pregnancy, researchers found significantly smaller ovaries and uterus as well as fewer follicles. Data from the same research project also show abnormalities in boys – and old…

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Medical Xpress broke the news in Douglas, United Kingdom on Tuesday, September 8, 2026.
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