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The Impact of Plasticizer on the Drug Supersaturation Maintenance by Polymer - Pharma Excipients
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The Impact of Plasticizer on the Drug Supersaturation Maintenance by Polymer - Pharma Excipients
Abstract Objective One of the widely used methods to inhibit precipitation and provide supersaturation stabilization of poorly water-soluble drugs in aqueous solution is the use of polymers. To enhance the precipitation inhibitory effect of a polymer, its fast dissolution is a prerequisite, while many polymers have extended-release profiles. The present study investigates the impact of four plasticizers, including glycerol (GLY), polyethylene gl…
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