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Top Pharma Excipients News

Oral administration of nanozyme-armed probiotic Escherichia coli Nissle 1917 with ROS scavenging for inflammatory bowel disease therapy - Pharma Excipients

Abstract Inflammatory bowel disease (IBD) represents a group of chronic, non-specific gastrointestinal disorders characterized by pathological overproduction of reactive oxygen species (ROS). Current therapeutic interventions, including conventional drugs and oral probiotics, are frequently limited by their vulnerability to the harsh gastrointestinal environment. To address these challenges, we have developed a novel engineered bacterium, design…Read Article

Netherlands · Netherlands

Effect of Quantitative Structural Properties and Drug Formulation in Four Cannabinoids (Cannabidiol, Cannabigerol, Cannabichromene, and Cannabinol) on Their Lymphatic Transport after Enteral Administration in Rats - Pharma Excipients

Abstract The effect of quantitative structural properties of drugs on the extent of lymphatic transport is not well understood. Our study aimed to describe these principles in four cannabinoids, cannabidiol (CBD), cannabigerol (CBG), cannabichromene (CBC), and cannabinol (CBN) administered as oil solutions and nanoemulsions. A series of studies in jugular vein cannulated rats and anesthetized mesenteric lymph duct cannulated rats was conducted t…Read Article

Cairo, Egypt · Cairo

Eprosartan loaded mesoporous silica nanoparticles embedded in mucoadhesive buccal films: A strategy for improved bioavailability - Pharma Excipients

Abstract Eprosartan is a selective angiotensin receptor blocker used to treat essential hypertension. However, it has a low oral bioavailability of only 13 % as it is categorized as BCS class II and undergoes first-pass metabolism. Therefore, incorporating eprosartan into mesoporous silica nanoparticles (MSNs)-loaded buccal film might augment its bioavailability. The MSNs were formulated using the incipient wetness method, and an I-optimal desig…Read Article

Gallic Acid-Loaded Transethosomal Gel for Enhanced Topical Delivery and Sustained Therapeutic Efficacy in Psoriasis Management: Formulation, Optimization, In Vitro and Ex Vivo Assessment - Pharma Excipients

Abstract Psoriasis is a chronic, non-communicable inflammatory skin disorder for which current treatments are largely limited to symptomatic management. These approaches were often challenged with limitations like inadequate skin penetration, frequent dosing requirements, potential toxicity, and low patient adherence, ultimately compromising therapeutic outcomes and affecting patients’ health. To obviate the flaws that are hindering the clinical…Read Article

Assessment of the plasticity of dry granulated particles (mini-tablets) and its relationship to their tabletability - Pharma Excipients

Abstract Mini-tablets of different proportions of α-lactose monohydrate (LAC) and microcrystalline cellulose (MCC) were prepared by uniaxial compaction and served as surrogate granules. The inverted Adams coefficient i.e., α−1 was derived from bulk mini-tablet compression data and used as an indication of granule plastic deformation. The correlation of the parameter to single granule deformability assessed from uniaxial single mini-tablet compre…Veghel · Veghel Read Article

Encapsulation of aceclofenac hydrogel-based solid dispersion for sustained delivery - Pharma Excipients

Abstract Purpose: To develop aceclofenac hydrogel-based solid dispersions (AC-HSDs) encapsulated in two modified gelatin capsules (MGCs as MGX1 and MGX2) for sustained drug delivery. Methods: The AC-HSDs were prepared with Eudragit L 100 (EL1 – EL5) and hydroxypropyl methylcellulose acetate succinate (HP1 – HP5) at various drug: carrier ratios (1:1, 1:2, 2:1, 1:3, using solvent evaporation technique and characterized by percentage encapsulation …Read Article

Continuous supercritical emulsion extraction for the co-encapsulation of butyrate and propionate nanoparticles in PLGA microparticles for colonic release - Pharma Excipients

Abstract Postbiotics are substances released or produced by the metabolic activity of microorganisms that have a beneficial effect on the host. Among the postbiotics, butyrate and propionate stand out for their excellent anti-inflammatory and immunomodulatory properties in the fight against intestinal diseases. However, these substances have some limitations as they are low molecular weight compounds that have limited clinical use due to unfavor…Denmark · Denmark Read Article

Intradermal delivery of nanohybrid thermosensitive hydrogels loaded with chondroitin sulphate coated pomegranate lipid carriers via hollow microneedles for effective rheumatoid arthritis management - Pharma Excipients

Abstract Rheumatoid Arthritis (RA) is a common inflammatory arthritis type that significantly affects physical functions, leading to restrictions in daily activities. The current study aims to develop an effective nano-based drug delivery system for RA management using pomegranate peel extract (POM). POM was encapsulated in nanostructured lipid carriers (NLCs), coated with chondroitin sulphate (CHS) to actively target CD44 receptors that are ove…France · France Read Article

Process and Formulation Parameters Governing Polymeric Microparticle Formation via Sequential NanoPrecipitation (SNaP) - Pharma Excipients

Abstract Polymeric microparticles (MPs) are valuable drug delivery vehicles for extended-release applications, but current manufacturing techniques present significant challenges in balancing size control with scalability. Industrial synthesis processes provide high throughput but limited precision, while laboratory-scale technologies offer precise control but poor scalability. This study explores Sequential NanoPrecipitation (SNaP), a two-step …United States · United States Read Article

The Impact of Plasticizer on the Drug Supersaturation Maintenance by Polymer - Pharma Excipients

Abstract Objective One of the widely used methods to inhibit precipitation and provide supersaturation stabilization of poorly water-soluble drugs in aqueous solution is the use of polymers. To enhance the precipitation inhibitory effect of a polymer, its fast dissolution is a prerequisite, while many polymers have extended-release profiles. The present study investigates the impact of four plasticizers, including glycerol (GLY), polyethylene gl…Read Article

Scale Up Your Scale Up – Webinar for Optimizing Tablet Development for Production Success - Pharma Excipients

We are glad to present our next webinar with TaBlitz and Natoli Scientific: Scale Up Your Scale Up – Optimizing Tablet Development for Production Success Join us for an insightful webinar, “Scale Up Your Scale Up,” designed for pharmaceutical and nutraceutical professionals seeking to streamline tablet development from R&D to production. This session will explore a material-sparing approach that leverages key tablet quality attributes—true densi…Telford · Telford Read Article

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Top Pharma Excipients News

Oral administration of nanozyme-armed probiotic Escherichia coli Nissle 1917 with ROS scavenging for inflammatory bowel disease therapy - Pharma Excipients

Effect of Quantitative Structural Properties and Drug Formulation in Four Cannabinoids (Cannabidiol, Cannabigerol, Cannabichromene, and Cannabinol) on Their Lymphatic Transport after Enteral Administration in Rats - Pharma Excipients

Eprosartan loaded mesoporous silica nanoparticles embedded in mucoadhesive buccal films: A strategy for improved bioavailability - Pharma Excipients

Gallic Acid-Loaded Transethosomal Gel for Enhanced Topical Delivery and Sustained Therapeutic Efficacy in Psoriasis Management: Formulation, Optimization, In Vitro and Ex Vivo Assessment - Pharma Excipients

Assessment of the plasticity of dry granulated particles (mini-tablets) and its relationship to their tabletability - Pharma Excipients

Encapsulation of aceclofenac hydrogel-based solid dispersion for sustained delivery - Pharma Excipients

Continuous supercritical emulsion extraction for the co-encapsulation of butyrate and propionate nanoparticles in PLGA microparticles for colonic release - Pharma Excipients

Intradermal delivery of nanohybrid thermosensitive hydrogels loaded with chondroitin sulphate coated pomegranate lipid carriers via hollow microneedles for effective rheumatoid arthritis management - Pharma Excipients

Process and Formulation Parameters Governing Polymeric Microparticle Formation via Sequential NanoPrecipitation (SNaP) - Pharma Excipients

The Impact of Plasticizer on the Drug Supersaturation Maintenance by Polymer - Pharma Excipients

Scale Up Your Scale Up – Webinar for Optimizing Tablet Development for Production Success - Pharma Excipients

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Gallic Acid-Loaded Transethosomal Gel for Enhanced Topical Delivery and Sustained Therapeutic Efficacy in Psoriasis Management: Formulation, Optimization, In Vitro and Ex Vivo Assessment - Pharma Excipients

Assessment of the plasticity of dry granulated particles (mini-tablets) and its relationship to their tabletability - Pharma Excipients

Encapsulation of aceclofenac hydrogel-based solid dispersion for sustained delivery - Pharma Excipients

Continuous supercritical emulsion extraction for the co-encapsulation of butyrate and propionate nanoparticles in PLGA microparticles for colonic release - Pharma Excipients

Intradermal delivery of nanohybrid thermosensitive hydrogels loaded with chondroitin sulphate coated pomegranate lipid carriers via hollow microneedles for effective rheumatoid arthritis management - Pharma Excipients

Process and Formulation Parameters Governing Polymeric Microparticle Formation via Sequential NanoPrecipitation (SNaP) - Pharma Excipients

The Impact of Plasticizer on the Drug Supersaturation Maintenance by Polymer - Pharma Excipients

Scale Up Your Scale Up – Webinar for Optimizing Tablet Development for Production Success - Pharma Excipients