Certain Gut Bacteria May Intensify Inflammatory Responses to Vaccines
Researchers found that 171 adults with more inflammatory gut bacteria were more likely to develop fever after mRNA vaccination.
- A study in Science by researcher Kelsey Huus linked gut bacteria to fever after mRNA vaccination in 171 adults, investigating whether the microbiome influences immune activity and vaccine reactions.
- Specifically, Lachnospiraceae bacteria produce the protein flagellin, which intensifies inflammatory immune pathways; people with high-fever symptoms tended to share microbiome traits, including greater gut inflammation and higher flagellin expression.
- Ruth Ley, senior author at the Max Planck Institute for Biology in Germany, used genetically engineered mice to confirm a direct link between flagellin and fever; mice lacking flagellin receptors showed reduced immune responses.
- Vegetarian diets correlated with lower flagellin levels, while diets characterized by greater fat or processed-food intake were associated with the inflammatory, fever-associated microbiome, suggesting dietary choices influence vaccine responses.
- Bali Pulendran writes that people might one day prepare for vaccination by targeting microbial ecology and diet as deliberately as vaccines are formulated, as research suggests diet could reduce vaccine-related inflammation without compromising immune protection.
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13 Articles
Gut microbes help set the body's inflammatory response to vaccination
Vaccination is one of the most important tools for preventing infectious diseases and protecting public health. However, immune responses after vaccination vary dramatically from person to person: If you give many people the exact same vaccine, some will experience side effects such as fever and flulike symptoms while others feel fine.
Vaccination is one of the most effective measures to protect the health of the population and to contain serious infectious diseases. Even using the same vaccines, people often react quite differently to vaccination – why was so far unclear.
Researchers observed differences in microorganisms in people who developed severe fever after vaccination
If after getting the covid-19 vaccine you spent an entire night shivering in bed with 38oC fever while your partner had not even hurt his arm, the answer is not in his bad luck, in the genetics or in the drug lot. It is in his intestine.A research led by the Max Planck Institute (Germany) and published this week in the magazine ' Science ' has found that the intestinal microbiota acts as a previous 'thermostate' that conditions our body's inflam…
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