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The Aged Stem Cell Niche Obstructs Hematopoietic Stem Cell Rejuvenation via Transplantation
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The Aged Stem Cell Niche Obstructs Hematopoietic Stem Cell Rejuvenation via Transplantation
One of the reasons why the immune system declines with age is that hematopoietic stem cell populations that are resident in the bone marrow and responsible for creating immune cells become progressively more damaged and dysfunctional over time. It isn't just the stem cells, however. Stem cells reside within structures of supporting cells known as niches. The niche itself becomes damaged and dysfunction, contributing to the problems exhibited by …
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