Synaptic Spread versus Selective Vulnerability Hypotheses of Neurodegenerative Disease

Synaptic Spread versus Selective Vulnerability Hypotheses of Neurodegenerative Disease

The authors of this open access paper provide an overview of two viewpoints on the onset and progression of neurodegenerative conditions. The biochemistry of the brain is exceptionally complex, and its dysfunction is also complex. It is clear that the aggregation of a few forms of altered protein is important in neurodegeneration, but exactly how and why it is important remains an active area of research. There are points of consensus, points of…