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Solid lipid–threshold guided chitosan coating of NLCs for improved gastrointestinal stability and curcumin bioavailability - Pharma Excipients
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Solid lipid–threshold guided chitosan coating of NLCs for improved gastrointestinal stability and curcumin bioavailability - Pharma Excipients
Abstract Chitosan-coated nanostructured lipid carriers (CS-NLCs) were engineered to overcome the gastrointestinal instability and limited absorption of glycerol distearate (GDS)/medium-chain triglyceride (MCT)-based NLCs. Using a dropwise coating method, we systematically evaluated the impact of chitosan coating on digestive stability and intestinal permeability through in vitro digestion models, Ussing chamber assays, and confocal laser scannin…
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