SAPS3 Inhibition in Mice Increases AMPK to Modestly Improve Metabolism and Slows Aging

SAPS3 Inhibition in Mice Increases AMPK to Modestly Improve Metabolism and Slows Aging

Researchers here report on a novel approach to slow aging and extend life in mice by interfering in the activity of a protein involved in the regulation of metabolism. The researchers find that SAPS3 expression increases with age, and deletion of this gene slows metabolic aging. SAPS3 is a component of a protein complex that reduces levels of AMPK. Upregulation of AMPK is known to slow aging, and here that is achieved by disabling the SAPS3-rela…