Megabodies Expand the Nanobody Toolkit for Protein Structure Determination by Single-Particle Cryo-EM

Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM

Nanobodies are popular and versatile tools for structural biology. They have a compact single immunoglobulin domain organization, bind target proteins with high affinities while reducing their conformational heterogeneity and stabilize multi-protein complexes. Here we demonstrate that engineered nanobodies can also help overcome two major obstacles that limit the resolution of single-particle cryo-electron microscopy reconstructions: particle si…

A nanobody-based therapeutic targeting Nipah virus limits viral escape

A nanobody-based therapeutic targeting Nipah virus limits viral escape Nipah virus (NiV) and Hendra virus (HeV) are highly pathogenic henipaviruses without approved human vaccines or therapies. Here, we report on a highly potent bispecific therapeutic that combines an anti-fusion glycoprotein nanobody with an anti-receptor-binding glycoprotein (RBP) antibody to deliver a dual-targeting biologic that is resistant to viral escape. We show that the…

Nipah Vaccines Near Human Trials to Protect Global Health - Get World Wide Update with Hourly Prime News

The Nipah virus, a highly pathogenic zoonotic virus capable of causing severe illness and death in humans, has long been considered a significant threat to global health. Known for its outbreak potential and lack of specific treatments or vaccines, Nipah’s emergence reminds the world of the critical need for rapid advancements in infectious disease prevention. Recently, exciting developments have brought us closer to a viable solution: the adven…