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Microbiome Differential Abundance Methods Produce Different Results Across 38 Datasets

Summary by Nature
Identifying differentially abundant microbes is a common goal of microbiome studies. Multiple methods are used interchangeably for this purpose in the literature. Yet, there are few large-scale studies systematically exploring the appropriateness of using these tools interchangeably, and the scale and significance of the differences between them. Here, we compare the performance of 14 differential abundance testing methods on 38 16S rRNA gene da…

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Multiple Sclerosis Research Blog broke the news in on Thursday, July 3, 2025.
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