Material-sparing method development for liquid-to-solid ratio determination for wet granulation process development - Pharma Excipients

Material-sparing method development for liquid-to-solid ratio determination for wet granulation process development - Pharma Excipients

Abstract The liquid-to-solid (L/S) ratio is a key process parameter in wet granulation processes, which ensures that the final granules meet the desired quality attributes. Mixer torque rheometer (MTR) is an established instrument to determine this parameter by measuring torque changes as a function of liquid content. Therefore, this study aimed to assess whether IKA Magic Plant and Freeman FT4 powder rheometer could serve as reliable alternativ…