Lipid-Coated Mesoporous Silica Particles for pHSensitive Tumor-Targeted Paclitaxel: Development, Characterization - Pharma Excipients

Lipid-Coated Mesoporous Silica Particles for pHSensitive Tumor-Targeted Paclitaxel: Development, Characterization - Pharma Excipients

Abstract Nanoparticle carriers can selectively deliver the drug cargo to tumor cells, thus having the ability to prevent early drug release, reduce non-specific cell binding, and prolong in vivo drug retention. We constructed paclitaxel (PTX)-loaded lipid-shell mesoporous silica nanoparticles (LMSNs) for targeted anti-cancer drug delivery. The physical properties of PTX-LMSNs were analyzed by scanning electron microscopy (SEM) and transmission e…