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JCI The human glucocorticoid receptor variant rs6190 increases blood cholesterol and promotes atherosclerosis
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JCI The human glucocorticoid receptor variant rs6190 increases blood cholesterol and promotes atherosclerosis
Elevated cholesterol poses cardiovascular risks. The glucocorticoid receptor (GR) harbors a still undefined role in cholesterol regulation. Here, we report that a coding SNP in the gene encoding the GR, rs6190, is associated with increased cholesterol in women according to UK Biobank and All of Us (NIH) datasets. In SNP-genocopying mice, we found that the SNP enhanced hepatic GR activity to transactivate Pcsk9 and Bhlhe40, negative regulators of…
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