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ScienceSomatically acquired mutations in the E1 ubiquitin-activating enzyme UBA1 within hematopoietic stem and progenitor cells (HSPCs) were recently identified as the cause of the adult-onset autoinflammatory syndrome VEXAS (vacuoles, E1 enzyme, X linked, autoinflammatory, somatic)1. UBA1 mutations in VEXAS lead to clonal expansion within the HSPC and myeloid, but not lymphoid, compartments. Despite its severity and prevalence, the mechanisms whereby …See the Story
Independent mechanisms of inflammation and myeloid bias in VEXAS syndrome
100% Center coverage: 2 sources
Swansea University · SwanseaAn international research effort led by a team from Swansea University in the U.K. has identified a mitochondrial protein that plays a pivotal role in driving the overactivity of immune cells responsible for autoimmune diseases such as rheumatoid arthritis and type 1 diabetes. The study, published in Nature Communications, has identified the protein ABHD11 as central to the metabolic changes that occur in autoimmunity causing T cells to attack h…See the Story
