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Top jci.org News

Women with Endometriosis-Associated Infertility Are More Likely to Become Pregnant, Study Reveals
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Women with Endometriosis-Associated Infertility Are More Likely to Become Pregnant, Study Reveals

67% Center coverage: 3 sources
A landmark 30-year study of over four million women in England has revealed that women with endometriosis-associated infertility are significantly more likely to become pregnant compared to those with infertility from other causes.See the Story
Breakthrough Study Reveals Killing Power of CD4 T Cells Against Cancer
Cancer

Breakthrough Study Reveals Killing Power of CD4 T Cells Against Cancer

100% Center coverage: 2 sources
In the fight against cancer, immunotherapy - which aims to boost the body's natural defences against cancer - is experiencing remarkable growth. Most of these treatments are based on CD8 T lymphocytes, ''killer cells'' able to eliminate diseased cells.See the Story
Rarely Studied RNA Linked to Triple-Negative Breast Cancer
Breast Cancer · Cold Spring Harbor

Rarely Studied RNA Linked to Triple-Negative Breast Cancer

100% Center coverage: 1 sources
Breast cancer is one of the most common cancers among women in the United States. Thanks to decades of fundamental research, it's also one of the most curable.See the Story

WSTF Nuclear Autophagy Regulates Chronic but Not Acute Inflammation

100% Center coverage: 1 sources
Acute inflammation is an essential response that our bodies use to combat infections1. However, in the absence of infections, chronic inflammation can have a pivotal role in the onset and progression of chronic diseases, such as arthritis, cancer, autoimmune disorders, metabolic-dysfunction-associated steatohepatitis (MASH), and most ageing-associated pathologies2,3. The underlying mechanisms that distinguish chronic inflammation from its acute …NatureSee the Story

Engineered protein silences harmful T cells in autoimmune disease

100% Center coverage: 1 sources
An engineered protein turns off the kind of immune cells most likely to damage tissue as part of Type-1 diabetes, hepatitis, multiple sclerosis, shows a new study in mice.Multiple SclerosisSee the Story

JCI The gut microbiome controls reactive astrocytosis during Aβ amyloidosis via propionate-mediated regulation of IL-17

Accumulating evidence implicates the gut microbiome (GMB) in the pathogenesis and progression of Alzheimer’s disease (AD). We recently showed that the GMB regulates reactive astrocytosis and Aβ plaque accumulation in a male APPPS1-21 AD mouse model. Yet, the mechanism(s) by which GMB perturbation alters reactive astrocytosis in a manner that reduces Aβ deposition remain unknown. Here, we performed metabolomics on plasma from mice treated with an…RegulationRead Article

JCI Targeting MTAP increases PARP inhibitor susceptibility in triple-negative breast cancer through a feed-forward loop

100% Left coverage: 1 sources
Triple-negative breast cancer (TNBC) represents the most malignant subtype of breast cancer. The clinical application of PARP inhibitors (PARPi) is limited by the low frequency of BRCA1/2 mutations in TNBC. Here, we identified that MTAP deletion sensitized genotoxic agents in our clinical cohort of metastatic TNBC. Further study demonstrated that MTAP deficiency or inhibition rendered TNBC susceptibility to chemotherapeutic agents, particularly …Breast Cancer · United StatesSee the Story

Clinical Validation of an AI-Based Pathology Tool for Scoring of Metabolic Dysfunction-Associated Steatohepatitis

100% Center coverage: 1 sources
Metabolic dysfunction-associated steatohepatitis (MASH) is a major cause of liver-related morbidity and mortality, yet treatment options are limited. Manual scoring of liver biopsies, currently the gold standard for clinical trial enrollment and endpoint assessment, suffers from high reader variability. This study represents the most comprehensive multisite analytical and clinical validation of an artificial intelligence (AI)-based pathology sys…See the Story

JCI DNA demethylating agents suppress preclinical models of synovial sarcoma

Synovial sarcoma is an aggressive soft-tissue cancer driven by the chimeric SS18::SSX fusion oncoprotein, which disrupts chromatin remodeling by combining two antagonistic transcriptional regulators. SS18 participates in BAF complexes that open chromatin, while the SSX genes are cancer-testis antigens that interface with chromatin decorated with monoubiquitinated histone H2A placed by polycomb repressive complex activity. Because KDM2B brings po…Read Article

JCI GluN2B suppression restores phenylalanine-induced neuroplasticity and cognition impairments in a mouse model of phenylketonuria

Phenylketonuria (PKU), an inborn error of phenylalanine (Phe) metabolism, is a common cause of intellectual disability. However, the mechanisms by which elevated Phe levels cause cognitive impairment remain unclear. Here, we show that submillimolar Phe perturbs synaptic plasticity through the hyperactivation of GluN2B-containing NMDARs. PahEnu2 PKU model mice exhibited submillimolar and supramillimolar concentrations of Phe in the cerebrospinal …United States · United StatesRead Article

JCI LAG3 regulates antibody responses in a murine model of kidney transplantation

Lymphocyte activation gene 3 (LAG3) is a coinhibitory receptor expressed by various immune cells. Although the immunomodulatory potential of LAG3 is being explored in cancer and autoimmunity, there is no information on its role after organ transplantation. Our study investigated the functions of LAG3 in a mouse model of renal allograft rejection. LAG3–/– recipients rapidly rejected MHC-mismatched renal allografts that were spontaneously accepted…Read Article

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