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JCI Pharmacokinetics and pharmacodynamics of a long-acting monoclonal antibody against malaria in African adults
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JCI Pharmacokinetics and pharmacodynamics of a long-acting monoclonal antibody against malaria in African adults
BACKGROUND CIS43LS is a long-acting mAb that targets the Plasmodium falciparum circumsporozoite protein. A phase II trial showed that a single dose of CIS43LS conferred > 85% sterile protection against infection in Malian adults over 6 months. Understanding the pharmacokinetics and pharmacodynamics (PK/PD) of CIS43LS is critical for the further development of CIS43LS and other antimalaria mAbs.METHODS Using 3,777 serum samples collected from 348…
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