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JCI Myeloid cell genome-wide screen identifies variants associated with Mycobacterium tuberculosis–induced cytokine transcriptional responses
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For the first time in Senegal, researchers from the Institute for Health Research, Epidemiological Surveillance and Training (IRESSEF), led by Professor Souleymane Mboup, have made a major scientific breakthrough: the complete sequencing of the genome of the Mycobacterium tuberculosis complex, the bacterium responsible for tuberculosis. This prowess was carried out in the framework of the national drug resistance survey 2023, in partnership with…
JCI Myeloid cell genome-wide screen identifies variants associated with Mycobacterium tuberculosis–induced cytokine transcriptional responses
Immune and clinical outcomes to Mycobacterium tuberculosis (Mtb) infection vary greatly between individuals, yet the underlying genetic and cellular mechanisms driving this heterogeneity remain poorly understood. We performed a cellular genome-wide association study to identify genetic variants associated with Mtb-induced monocyte transcriptional expression of IL1B, IL6, TNF, and IFNB1 via RNA-Seq in a Ugandan cohort. Significantly associated va…
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