JCI Insights into protection against Mycobacterium tuberculosis infection: time to officially confirm another phenotype?

Contact tracing has been completed in Fáskrúðsfjörður after tuberculosis was diagnosed there last month. Forty people underwent tuberculosis tests. "There were 40 people we considered appropriate to screen, who had been in close contact with the person diagnosed with pulmonary tuberculosis. After these 40 individuals had undergone these preventive measures, we assessed that there were no signs that the tuberculosis had spread," says Eyjólfur Þor…

JCI Insights into protection against Mycobacterium tuberculosis infection: time to officially confirm another phenotype?

Immune correlates of protection against infection with Mycobacterium tuberculosis (Mtb) remain elusive. In this issue of the JCI, Dallmann-Sauer and authors demonstrate that lack of tuberculin skin test (TST) and interferon γ release assay (IGRA) conversion among people with HIV despite years-long Mtb exposure is associated with alveolar lymphocytosis, including specific poly-cytotoxic T cells, and M1-type alveolar macrophages with a stronger ex…