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JCI Insight Progressive HNF1A-MODY pathophysiology revealed by a translational mouse model
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JCI Insight Progressive HNF1A-MODY pathophysiology revealed by a translational mouse model
HNF1A-MODY, the most common monogenic diabetes, exhibits progressive β cell dysfunction, but existing mouse models fail to recapitulate human disease progression, limiting understanding of pathogenic mechanisms. We developed mice with heterozygous deletion of the Hnf1a transactivation domain (Hnf1a+/Δe4-10) to model human HNF1A haploinsufficiency, conducted cross-sectional metabolic characterization, and validated our findings in HNF1A-deficient…
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