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JCI Insight Maternal opioid use and hepatitis C infection disrupt the placental immune landscape and structure
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JCI Insight Maternal opioid use and hepatitis C infection disrupt the placental immune landscape and structure
Maternal opioid use disorder (OUD) poses substantial risks to maternal and fetal health. These adverse outcomes are believed to be mediated, in part, by changes in placental structure and function; however, few studies have addressed this question. Here, we utilized flow cytometry, histology, and spatial and single-cell transcriptomics to uncover the impact of OUD on placental tissues. Given that half of individuals with chronic OUD contract hep…
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