Key Protein Driving Autoimmune Inflammation Identified

Key Protein Driving Autoimmune Inflammation Identified

An international research effort led by a team from Swansea University in the U.K. has identified a mitochondrial protein that plays a pivotal role in driving the overactivity of immune cells responsible for autoimmune diseases such as rheumatoid arthritis and type 1 diabetes. The study, published in Nature Communications, has identified the protein ABHD11 as central to the metabolic changes that occur in autoimmunity causing T cells to attack h…

JCI Immune cell quantification of in situ inflammation partitions human lupus nephritis into mechanistic subtypes

BACKGROUND In human lupus nephritis (LuN), tubulointerstitial inflammation (TII) is prognostically more important than glomerular inflammation. However, a comprehensive understanding of both TII complexity and heterogeneity is lacking.METHODS Herein, we used high-dimensional confocal microscopy, spatial transcriptomics, and specialized computer vision techniques to quantify immune cell populations and localize these within normal and diseased re…