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JCI IL-13 priming in precursors drives beige adipogenesis and enhances metabolic homeostasis
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JCI IL-13 priming in precursors drives beige adipogenesis and enhances metabolic homeostasis
Accumulating evidence from rodent and human studies indicates that the activity of thermogenic adipocytes positively correlates with optimal metabolic function. In this issue of the JCI, Yesian et al. uncover a paracrine signaling pathway from type 2 innate lymphoid cells to preadipocytes via IL-13 that increases beige adipogenesis through a PPARγ-dependent pathway. Mice with deletion of Il13ra1 demonstrated glucose dysregulation, and variants n…
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