JCI Expanding clones, expanding aneurysms through macrophage-to-osteoclast differentiation

JCI Expanding clones, expanding aneurysms through macrophage-to-osteoclast differentiation

Abdominal aortic aneurysms (AAAs) are an age-related cause of sudden cardiac death and cardiovascular disease (CVD) morbidity with limited nonsurgical treatment options. In this issue of the JCI, Yonekawa et al. addressed the pathobiologic mechanisms of clonal hematopoiesis (CH), the age-related acquisition of expanded somatic clones in blood cells, as a potential driver of AAA. CH prevalence was high in patients being treated for AAA, and faste…