JCI Acute kidney injury triggers hypoxemia by lung intravascular neutrophil retention that reduces capillary blood flow

JCI Acute kidney injury triggers hypoxemia by lung intravascular neutrophil retention that reduces capillary blood flow

Sterile acute kidney injury (AKI) is common in the clinic and frequently associated with unexplained hypoxemia that does not improve with dialysis. AKI induces remote lung inflammation with neutrophil recruitment in mice and humans, but which cellular cues establish neutrophilic inflammation and how it contributes to hypoxemia is not known. Here we report that AKI induced rapid intravascular neutrophil retention in lung alveolar capillaries with…