Understanding Sex-Based Differences and the Role of Bone Morphogenetic Protein Signaling in Alzheimer's Disease

Understanding sex-based differences and the role of bone morphogenetic protein signaling in Alzheimer's disease

Alzheimer's disease (AD) is a serious neurodegenerative disease largely affecting older adults. Apart from age, it also shows sex-based differences, with women being more at risk. However, the origin of these differences remains unknown.

In Search of Mechanisms to Explain the Sex Difference in Alzheimer's Disease Outcomes

As you may know, there are significant differences in incidence and outcomes of Alzheimer's disease between the sexes. In research, differences of this nature can help in developing a better understanding of which mechanisms are more versus less important in the disease process, and so guide efforts to produce therapies. The biochemistry of the brain is enormously complex, and thus so is the pathology of Alzheimer's disease. It remains the case …