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HMGB1 is an Important Secreted Factor in Transmission of Cellular Senescence
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HMGB1 is an Important Secreted Factor in Transmission of Cellular Senescence
The signal molecules secreted by senescent cells can encourage other nearby cells to also become senescent. Thus the high burden of lingering senescent cells in aged tissues is both directly harmful to tissue structure and function, but also indirectly harmful by encouraging further growth of that burden of cellular senescence. The research community has investigated which of the many different components of the senescence-associated secretory p…
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