3BTRON: A Blood-Brain Barrier Recognition Network

3BTRON: A Blood-Brain Barrier Recognition Network

The blood-brain barrier (BBB) plays a crucial role in maintaining brain homeostasis. During ageing, the BBB undergoes structural alterations. Electron microscopy (EM) is the gold standard for studying the structural alterations of the brain vasculature. However, analysis of EM images is time-intensive and can be prone to selection bias, limiting our understanding of the structural effect of ageing on the BBB. Here, we introduce 3BTRON, a deep le…

Reducing Microglial Senescence Slows Pathology in an Alzheimer's Disease Mouse Model

Microglia are innate immune cells of the brain, similar to macrophages elsewhere in the body. A growing body of evidence points to maladaptive inflammatory behavior of microglia in the aging brain as an important contribution to the onset and progression of neurodegenerative conditions such as Alzheimer's disease. Some microglia become inflammatory in response to the damaged environment of aged brain tissue, but others have become senescent. Sen…

Glial Reactivity Links to Synaptic Dysfunction in Aging

A groundbreaking study published in Nature Communications is reshaping our understanding of the cellular interactions underlying aging and Alzheimer’s disease, revealing that glial cell reactivity is a critical driver of synaptic dysfunction. Researchers Rohden, Ferreira, Bellaver, and colleagues meticulously charted the complex interplay between glial activation and synaptic health, offering new avenues for therapeutic interventions […]

Glial Reactivity Correlates with Synaptic Dysfunction across Aging and Alzheimer’s Disease

Scientists investigated the association between glial reactivity and synaptic dysfunction biomarkers in cerebrospinal fluid from 478 individuals in cognitively unimpaired and cognitively impaired individuals. [Nature Communications] Full Article