Gastroretentive systems for prolonged release of metformin based on osmotically driven expansion - Pharma Excipients
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Gastroretentive systems for prolonged release of metformin based on osmotically driven expansion - Pharma Excipients
Abstract Metformin is a relatively old drug mainly used to treat type 2 and gestational diabetes, which needs to be administered two or three times a day in high doses. It has a high aqueous solubility and is poorly absorbed following oral intake. Aiming to achieve a gastroretentive formulation for prolonged release of this drug, an expandable device based on an osmotically driven mechanism (ORODS, Organ-Retentive Osmotically Driven System) was …
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