Fabrication and Ex-vivo Evaluation of Olanzapine Nanoparticles Based Dissolved Microneedle for Transdermal Delivery - Pharma Excipients
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Fabrication and Ex-vivo Evaluation of Olanzapine Nanoparticles Based Dissolved Microneedle for Transdermal Delivery - Pharma Excipients
Abstract Olanzapine (OLZ) is classified as a typical antipsychotic drug utilized for treatment of schizophrenia, it possesses poor oral bioavailability (60%) due to low solubility and first-pass hepatic metabolism. Hence, the aim of present work is to fabricate and evaluate an olanzapine nanoparticle dissolved microneedles for transdermal delivery to overcome the problems that associated with drug orally, in addition to the ease of administering…
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