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Encapsulation of aceclofenac hydrogel-based solid dispersion for sustained delivery - Pharma Excipients
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Encapsulation of aceclofenac hydrogel-based solid dispersion for sustained delivery - Pharma Excipients
Abstract Purpose: To develop aceclofenac hydrogel-based solid dispersions (AC-HSDs) encapsulated in two modified gelatin capsules (MGCs as MGX1 and MGX2) for sustained drug delivery. Methods: The AC-HSDs were prepared with Eudragit L 100 (EL1 – EL5) and hydroxypropyl methylcellulose acetate succinate (HP1 – HP5) at various drug: carrier ratios (1:1, 1:2, 2:1, 1:3, using solvent evaporation technique and characterized by percentage encapsulation …
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