Skip to main content
institutional access

You are connecting from
Lake Geneva Public Library,
please login or register to take advantage of your institution's Ground News Plan.

Published • loading... • Updated

Eli Lilly says closely watched combo obesity regimen boosts weight loss in mid-stage trial

The regimen also lowered A1C by up to 2.9% and moved into Phase 3 planning after meeting the study's main goals.

  • On Wednesday, Eli Lilly reported its experimental combination regimen showed greater weight loss than tirzepatide alone in a mid-stage trial targeting patients with obesity and Type 2 diabetes.
  • The combination treatment links eloralintide with tirzepatide, hitting three hormonal pathways including amylin, and yielded 23.3% weight loss in the 48-week Phase 2 trial.
  • Adding 3-milligram of eloralintide to tirzepatide led to 17% weight loss over 16 weeks, while the combo treatment reduced A1C by up to 2.9% versus 2.4% for tirzepatide alone.
  • Patients on the combination regimen discontinued treatment at rates of 10.8% to 27% due to side effects, though Ken Custer, president of Lilly Cardiometabolic Health, cautioned against over-interpreting these rates.
  • Lilly plans to advance the combination product into Phase 3 studies by the end of 2026, positioning the regimen as a competitor to Novo's next-generation obesity treatment CagriSema.
Insights by Ground AI

9 Articles

Think freely.Subscribe and get full access to Ground NewsSubscriptions start at $9.99/yearSubscribe

Bias Distribution

  • 87% of the sources are Center
87% Center

Factuality Info Icon

To view factuality data please Upgrade to Premium

Ownership

Info Icon

To view ownership data please Upgrade to Vantage

STAT broke the news in Boston, United States on Wednesday, September 30, 2026.
Too Big Arrow Icon
Sources are mostly out of (0)

Similar News Topics

News
Feed Dots Icon
For You
Search Icon
Search
Blindspot LogoBlindspotLocal