Electroconvulsive Therapy Generates a Postictal Wave of Spreading Depolarization in Mice and Humans

Electroconvulsive therapy generates a postictal wave of spreading depolarization in mice and humans

Electroconvulsive therapy (ECT) is a fast-acting, highly effective, and safe treatment for medication-resistant depression. Historically, the clinical benefits of ECT have been attributed to generating a controlled seizure; however, the underlying neurobiology is understudied and unresolved. Using optical neuroimaging of neural activity and hemodynamics in a mouse model of ECT, we demonstrated that a second brain event follows seizure: cortical …

Progressive Prolonged Delirium After Electroconvulsive Therapy

Progressive Prolonged Delirium After Electroconvulsive Therapy Electroconvulsive therapy (ECT) is a safe, effective, and underutilized treatment for multiple psychiatric conditions.1 However, delirium is a common complication of ECT. Acute postictal delirium (

Repetitive Neuronal Activation Regulates Cellular Maturation State via Nuclear Reprogramming

Neural stimulation, such as electroconvulsive therapy (ECT) and repetitive transcranial magnetic stimulation (rTMS), are highly effective clinical interventions for a broad spectrum of psychiatric disorders, including depression and schizophrenia. However, their mechanism of action at the cell...

Electroconvulsive Therapy Triggers Spreading Depolarization Wave

In a groundbreaking study published in Nature Communications, researchers have unveiled a previously uncharted physiological phenomenon occurring after electroconvulsive therapy (ECT): a postictal wave of spreading depolarization observable in both mice and humans. This discovery sheds new light on the neural mechanisms activated during and after ECT, offering profound implications for our understanding of brain dynamics and therapeutic outcomes…