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Differential roles of NaV1.2 and NaV1.6 in neocortical pyramidal cell excitability
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Differential roles of NaV1.2 and NaV1.6 in neocortical pyramidal cell excitability
Mature neocortical pyramidal cells functionally express two sodium channel (NaV) isoforms: NaV1.2 and NaV1.6. These isoforms are differentially localized to pyramidal cell compartments, and as such are thought to contribute to different aspects of neuronal excitability. But determining their precise roles in pyramidal cell excitability has been hampered by a lack of tools that allow for selective, acute block of each isoform individually. Here, …
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