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Top elifesciences.org News

Data-driven detection of concerning SARS-CoV-2 variants months in advance
Pandemic · Bolivia

Data-driven detection of concerning SARS-CoV-2 variants months in advance

100% Center coverage: 1 sources
Since the start of the SARS-CoV-2 pandemic, several variants of the virus have developed into Variants of Concern (VOCs), as classified by the World Health Organization (WHO). VOCs are virus variants that are predicted or known to cause large waves of infections due to their altered phenotypic characteristics and with a risk of altering disease severity, reducing vaccine effectiveness or otherwise leading to increased burden of health care syste…See the Story
Past Their Prime? Tool Use Declines with Age in Wild Chimpanzees
Nature · Oxford

Past Their Prime? Tool Use Declines with Age in Wild Chimpanzees

100% Center coverage: 1 sources
New research led by University of Oxford researchers has found that old age likely impacts the habitual tool-use behaviors of some wild chimpanzees—although the extent to which different individuals are affected appears to be highly variable. The findings have been published today in the journal eLife.See the Story
AI Startups: Heron Aims to Organize Business Data
Insurance · New York

AI Startups: Heron Aims to Organize Business Data

AI startup Heron said Tuesday (July 15) that it has raised $16.6 million in a Series A funding round. [contact-form-7] Heron automates the mounds of documents that businesses must manage, including PDFs, spreadsheets, emails, tax returns, bank statements, application documents and schedules. Its platform integrates with Salesforce, Zoho, Cloudsquare and Tasksuite, among other applications. Heron aims to help teams reduce manual work, en…See the Story

Mediodorsal thalamic nucleus mediates resistance to ethanol through Cav3.1 T-type Ca2+ regulation of neural activity

Thalamocortical activity is known to orchestrate sensory gating and consciousness switching. The precise thalamic regions involved, or the firing patterns related to the unconsciousness, remain unclear. Interestingly, the highly -expressed thalamic T-type calcium currents have been considered as a candidate for the ionic mechanism for the generation of thalamocortically driven change in conscious state. Here, we tested the hypothesis that Cav3.1…RegulationRead Article

Effective population size does not explain long-term variation in genome size and transposable element content in animals

Animal genomes exhibit a remarkable variation in size, but the evolutionary forces responsible for such variation are still debated. As the effective population size (Nee) reflects the intensity of genetic drift, it is expected to be a key determinant of the fixation rate of nearly-neutral mutations. Accordingly, the Mutational Hazard Hypothesis postulates lineages with low Nee to have bigger genome sizes due to the accumulation of slightly dele…Read Article

The myeloid cell-driven transdifferentiation of endothelial cells into pericytes promotes the restoration of BBB function and brain self-repair after stroke

Ischemic stroke, one of the leading causes of death in the world, is accompanied by the dysfunction of the blood-brain barrier (BBB), which aggravates neuron damage. However, the mechanisms underlying the restoration of BBB in the chronic stage after stroke remain unclear. Here, pericyte pool alterations and their consequences for BBB integrity and brain recovery were analyzed in the C57BL/6 mice stroke model. Lineage tracing, RNA-seq, and immun…Read Article

Evolutionary Biology: Embracing the complexity of cooperation

A theoretical framework for analyzing the evolution of nonlinear cooperative interactions is taking shape.Read Article

Differential roles of NaV1.2 and NaV1.6 in neocortical pyramidal cell excitability

Mature neocortical pyramidal cells functionally express two sodium channel (NaV) isoforms: NaV1.2 and NaV1.6. These isoforms are differentially localized to pyramidal cell compartments, and as such are thought to contribute to different aspects of neuronal excitability. But determining their precise roles in pyramidal cell excitability has been hampered by a lack of tools that allow for selective, acute block of each isoform individually. Here, …Read Article

EPHA4 signaling dysregulation links abnormal locomotion and the development of idiopathic scoliosis

Idiopathic scoliosis (IS) is the most common form of spinal deformity with unclear pathogenesis. In this study, we first reanalyzed the loci associated with IS, drawing upon previous studies. Subsequently, we mapped these loci to candidate genes using either location-based or function-based strategies. To further substantiate our findings, we verified the enrichment of variants within these candidate genes across several large IS cohorts encompa…China · ChinaRead Article

A mathematical model for ketosis-prone diabetes suggests the existence of multiple pancreatic β-cell inactivation mechanisms

Ketosis-prone diabetes mellitus (KPD) is a subtype of type 2 diabetes, which presents much like type 1 diabetes, with dramatic hyperglycemia and ketoacidosis. Although KPD patients are initially insulin-dependent, after a few months of insulin treatment, roughly 70% undergo near-normoglycemia remission and can maintain blood glucose without insulin, as in early type 2 diabetes or prediabetes. Here, we propose that these phenomena can be explaine…DiabetesRead Article

Malnutrition drives infection susceptibility and dysregulated myelopoiesis that persists after refeeding intervention

Undernutrition remains a major global health crisis, with nearly 1 billion people experiencing severe food insecurity. Malnourished individuals are especially vulnerable to infectious diseases, which is the leading cause of morbidity and mortality for this population. Despite the known link between undernutrition and infection susceptibility, the mechanisms remain poorly understood, and it is unclear whether refeeding can reverse nutritionally a…HealthRead Article

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