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Top elifesciences.org News

From Nigeria to Pakistan, TB Testing 'in a Coma' After U.S. Aid Cuts
South Africa · South Africa

From Nigeria to Pakistan, TB Testing 'in a Coma' After U.S. Aid Cuts

80% Right coverage: 5 sources
Moves by U.S. President Donald Trump have stalled vital research in South Africa and left TB survivors lacking support in India.See the Story
Triassic Reptiles Took 10,000 Mile Trips Through 'Hellish' Conditions, Study Suggests
Paleontology

Triassic Reptiles Took 10,000 Mile Trips Through 'Hellish' Conditions, Study Suggests

100% Center coverage: 3 sources
The forerunners of dinosaurs and crocodiles in the Triassic period were able to migrate across areas of the ancient world deemed completely inhospitable to life, new research suggests.See the Story
Study Finds Traditional Fecal Transplant Outperforms New Pill in Severe C. Diff. Cases
Medical · Chapel Hill

Study Finds Traditional Fecal Transplant Outperforms New Pill in Severe C. Diff. Cases

100% Center coverage: 1 sources
A new comparative study led by researchers at the UNC School of Medicine found that a new therapy for prevention of recurrent Clostridioides difficile infection may be less effective than traditional therapy when it comes to preventing severe disease over time.See the Story

A Multiplex of Connectome Trajectories Enables Several Connectivity Patterns in Parallel

Complex brain function comprises a multitude of neural operations in parallel and often at different speeds. Each of these operations is carried out across a network of distributed brain regions. How multiple distributed processes are facilitated in parallel is largely unknown. We postulate that such processing relies on a multiplex of dynamic network patterns emerging in parallel but from different functional connectivity (FC) timescales. Given…See the Story

Fingertip viscoelasticity enables human tactile neurons to encode loading history alongside current force

Human skin and its underlying tissues constitute a viscoelastic medium, implying that any deformation depends not only on the currently applied force, but also on the recent loading history. The extent to which this physical memory influences the signaling of first-order tactile neurons during natural hand use is not well understood. Here, we examined the effect of past loading on the responses of fast-adapting (FA-1) and slowly-adapting (SA-1 a…Read Article

Artificial intelligence approaches for tumor phenotype stratification from single-cell transcriptomic data

Single-cell RNA-sequencing (scRNA-seq) coupled with robust computational analysis facilitates the characterization of phenotypic heterogeneity within tumors. Current scRNA-seq analysis pipelines are capable of identifying a myriad of malignant and non-malignant cell subtypes from single-cell profiling of tumors. However, given the extent of intra-tumoral heterogeneity, it is challenging to assess the risk associated with individual cell subpopul…Artificial IntelligenceRead Article

BCAS2 promotes primitive hematopoiesis by sequestering β-catenin within the nucleus

Breast carcinoma amplified sequence 2 (BCAS2), a core component of the hPrP19 complex, plays crucial roles in various physiological and pathological processes. However, whether BCAS2 has functions other than being a key RNA-splicing regulator within the nucleus remains unknown. Here, we show that BCAS2 is essential for primitive hematopoiesis in zebrafish and mouse embryos. The activation of Wnt/β-catenin signaling, which is required for hematop…Read Article

Touch: A lasting impression

Touch-sensitive neurons in the fingertips take previous physical contacts into account when relaying tactile information to the brain.Read Article

Precise spatial tuning of visually driven alpha oscillations in human visual cortex

Neuronal oscillations at about 10 Hz, called alpha oscillations, are often thought to arise from synchronous activity across the occipital cortex and are usually largest when the cortex is inactive. However, recent studies measuring visual receptive fields have reported that local alpha power increases when cortex is excited by visual stimulation. This contrasts with the expectation that alpha oscillations are associated with cortical inactivity…Read Article

Neural substrates of cold nociception in Drosophila larva

Metazoans detect and differentiate between innocuous (non-painful) and/or noxious (harmful) environmental cues using primary sensory neurons, which serve as the first node in a neural network that computes stimulus-specific behaviors to either navigate away from injury-causing conditions or to perform protective behaviors that mitigate extensive injury. The ability of an animal to detect and respond to various sensory stimuli depends upon molecu…Read Article

A sex-specific Mendelian randomization-phenome-wide association study of body mass index

Higher body mass index has a wide range of harmful health effects, which sometimes appear to be more pronounced in men, suggesting that higher BMI may be one of the factors contributing to differences in lifespan between men and women.Read Article

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