Deletion of B125R increases protection induced by a genotype II African swine fever vaccine candidate.

Deletion of B125R increases protection induced by a genotype II African swine fever vaccine candidate.

Deletion of B125R increases protection induced by a genotype II African swine fever vaccine candidate. A modified live attenuated African swine fever genotype II virus, GΔDKE-CmutQ96R/K108D, with deletions of three genes, DP148R, EP153R, and K145R and expressing a mutated CD2v protein with a non-haemadsorbing phenotype, was further modified by first removing two reporter gene cassettes expressing fluorescent proteins. The B125R gene was then del…