Continuous supercritical emulsion extraction for the co-encapsulation of butyrate and propionate nanoparticles in PLGA microparticles for colonic release - Pharma Excipients

Continuous supercritical emulsion extraction for the co-encapsulation of butyrate and propionate nanoparticles in PLGA microparticles for colonic release - Pharma Excipients

Abstract Postbiotics are substances released or produced by the metabolic activity of microorganisms that have a beneficial effect on the host. Among the postbiotics, butyrate and propionate stand out for their excellent anti-inflammatory and immunomodulatory properties in the fight against intestinal diseases. However, these substances have some limitations as they are low molecular weight compounds that have limited clinical use due to unfavor…