Pomegranate-Linked Compound Shows Early Promise Against Deadly Heart Failure

Pomegranate-Linked Compound Shows Early Promise Against Deadly Heart Failure

Urolithin A, a compound linked to pomegranates, reversed signs of a hard-to-treat heart failure in mice and human heart tissue. The post Pomegranate-Linked Compound Shows Early Promise Against Deadly Heart Failure appeared first on StudyFinds.

Pomegranate-derived compound shows promise against preserved ejection fraction heart failure

A compound produced in the body after eating pomegranates improves heart function by up to 80% in a type of heart failure with limited treatment options.

Compound produced after eating pomegranates targets stiff-heart failure pathway, early tests suggest

A compound produced in the body after eating pomegranates improves heart function by up to 80% in a type of heart failure with limited treatment options.

Targeting PKGIα Cys42 attenuates cardiac dysfunction in heart failure with preserved ejection fraction

Abstract Heart failure with preserved ejection fraction (HFpEF) is a highly prevalent condition associated with substantial morbidity and mortality, yet effective therapeutic options remain limited. As oxidation of Cys 42 in cyclic guanosine monophosphate (cGMP)-dependent protein kinase Iα (PKGIα) can enhance vessel and diastolic relaxation, processes impaired in HFpEF, we sought to target this mechanism using natural compounds with predicted th…