Breakthrough Study Reveals Killing Power of CD4 T Cells Against Cancer

CD4+ T cell memory

Specialized subpopulations of CD4+ T cells survey major histocompatibility complex class II–peptide complexes to control phagosomal infections, help B cells, regulate tissue homeostasis and repair or perform immune regulation. Memory CD4+ T cells are positioned throughout the body and not only protect the tissues from reinfection and cancer, but also participate in allergy, autoimmunity, graft rejection and chronic inflammation. Here we provide …

Breakthrough study reveals killing power of CD4 T cells against cancer

In the fight against cancer, immunotherapy - which aims to boost the body's natural defences against cancer - is experiencing remarkable growth. Most of these treatments are based on CD8 T lymphocytes, ''killer cells'' able to eliminate diseased cells.

JCI Immune regeneration: implications for cancer immunotherapy and beyond

Cancer care is being transformed by therapies leveraging T lymphocytes to attack tumor cells. In parallel, recent basic discoveries have converged into a framework of lymphocyte-dependent immunity as a regenerative process that is sometimes outstripped by high-level engagement. In a stem cell–like fashion, selected T cells must balance mutually opposing demands of differentiation and self-renewal. Activating versus inhibitory signals to T cells …

How the immune system works in cancer prevention, radiation recovery, and nutritional support

How the immune system works in cancer prevention, radiation recovery, and nutritional support

Cancer: ’forgotten’ cells go on the offensive

30.06.2025 - UNIGE Immunologists have discovered the yet unsuspected anti-tumour potential of CD4 T lymphocytes, an important step towards a new kind of immunotherapy. In the fight against cancer, immunotherapy - which aims to boost the body's natural defences against cancer - is experiencing remarkable growth.