Assessment of the protective potential of coated microparticles in a fluidized bed against the simulated digestion - Pharma Excipients

Assessment of the protective potential of coated microparticles in a fluidized bed against the simulated digestion - Pharma Excipients

Abstract A strategy to enhance the protective effect of bioactive compounds in spray-dried microparticles is fluidized bed coating. Linseed oil was previously microencapsulated by spray drying using maltodextrin and whey protein as wall materials, and then coated with hydroxypropyl methylcellulose using a fluidized bed. A central composite rotatable design was used to assess the effects of coating solution flow rate (Q) and fluidizing air tempe…