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Assessment of the plasticity of dry granulated particles (mini-tablets) and its relationship to their tabletability - Pharma Excipients
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Assessment of the plasticity of dry granulated particles (mini-tablets) and its relationship to their tabletability - Pharma Excipients
Abstract Mini-tablets of different proportions of α-lactose monohydrate (LAC) and microcrystalline cellulose (MCC) were prepared by uniaxial compaction and served as surrogate granules. The inverted Adams coefficient i.e., α−1 was derived from bulk mini-tablet compression data and used as an indication of granule plastic deformation. The correlation of the parameter to single granule deformability assessed from uniaxial single mini-tablet compre…
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