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An APOE Mutation Inhibits cGAS-STING Signaling to Reduce Inflammation in the Aging Brain
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An APOE Mutation Inhibits cGAS-STING Signaling to Reduce Inflammation in the Aging Brain
Variants of the APOE gene (the most common labeled as APOE-ε2, APOE-ε3, and APOE-ε4) have been show to alter the risk of developing Alzheimer's disease. Work in recent years has pointed to effects on the behavior of microglia in the aging brain as the important mechanism is driving risk. Bad variants of APOE, predominantly APOE-ε4 in the population at large, lead to greater inflammation driven by activated and dysfunctional microglia. Good varia…
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