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Alpha-1 Antitrypsin Deficiency May Raise Preterm Birth Risk, Genetic Analysis Suggests

Mothers with two copies of the Pi*Z variant had pregnancies that were nine days shorter on average, researchers said.

Summary by Medical Xpress
Researchers at the University of Oulu have identified alpha-1 antitrypsin as a potential target for preventing spontaneous preterm birth. In a large genetic study of more than 200,000 mothers, a variant in the SERPINA1 gene, which encodes alpha-1 antitrypsin, was associated with shorter pregnancies.

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Medical Xpress broke the news in Douglas, United Kingdom on Thursday, September 3, 2026.
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