Loss of Y Chromosome in Men Could Be an Early Warning Sign of Cancer
Researchers found the loss in 1,000 tissue samples from 405 men and said it may help doctors identify cancer before tumors become visible.
7 Articles
7 Articles
Men are losing a key chromosome with age and it may be deadly
Aging men often lose the Y chromosome in a growing number of their cells—and it may be far more dangerous than once believed. This loss has been linked to heart disease, cancer, Alzheimer’s, and shorter lifespans. Researchers suspect Y-less cells may grow faster and disrupt normal body functions. What seemed like a minor genetic quirk could actually be a major driver of age-related disease.
Loss of Y chromosome in men could be an early warning sign of cancer
A study initiated by Dr. Dan Theodorescu, a physician-scientist at the University of Arizona Cancer Center, revealed that the loss of the Y chromosome in men's body tissue could pave the way for cancer to develop. According to research recently published in JCI Insights, the loss of the chromosome, which is common in men as they age, creates a preneoplastic field effect, a hidden zone of genetic vulnerability in normal tissue that provides ferti…
Invisible precursor: In tissues that still look normal under the microscope, the Y chromosome may already be missing more often when a tumor is located directly next to it. An analysis of 1,000 tissue samples from eleven organs shows a gradual increase in this loss from inconspicuous tissue to cancer. The result could help in the future to better detect early changes. Tucson (U.S.A.). [...] The article Y-chromosomal loss may indicate early on ca…
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