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A Comparative Study on the Coating Performance of Wurster, Bottom and Top Spray Fluidized Bed Coaters - Pharma Excipients
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A Comparative Study on the Coating Performance of Wurster, Bottom and Top Spray Fluidized Bed Coaters - Pharma Excipients
Abstract This study compared the coating applicability and performance of Wurster, bottom and top spray coaters. Two key indices – coating variability and efficiency – were estimated by the ray tracing model coupled with CFD-DEM simulations. The effects of the fluidizing gas velocity and the spray angle were investigated. The particle agglomeration in the three types of coaters was also compared indirectly from slip velocity, liquid bridge force…
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