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Hector Foundation Prize 2025 for Annika Reinke: “Metrics Reloaded” improves the quality of AI-supported image analysis

Annika Reinke's team developed Metrics Reloaded and the associated online tool with the aim of helping users select the most suitable algorithm for their task. Metrics Reloaded assists users in reliably evaluating the performance of AI algorithms in medical image analysis in a task-specific manner. This is because the informative value of such evaluations depends largely on the choice of suitable validation metrics—i.e., the key figures used to …Heidelberg, Germany · Heidelberg Read Article

Novel laboratory models pave the way for targeted therapies for childhood sarcomas

Sarcomas are rare but aggressive cancers that are the third most common type of cancer in children and adolescents after blood cancer and brain tumors. Soft tissue sarcomas, which arise from connective, muscle or fatty tissue, pose particular challenges for research: their enormous biological diversity and the lack of suitable preclinical models have significantly hampered the development of effective treatment approaches for decades. Compared t…Cancer · Heidelberg Read Article

Study Supports Lowering Colon Cancer Screening Age

Coverage: 14 sources

(MedPage Today) -- A single-center study supported recent U.S. recommendations that lowered the colorectal cancer screening age to 45. Screening colonoscopy outcomes were slightly less common in people ages 45-49 compared with those 50-54 years...Vaccines See the Story

Explainable artificial intelligence increases the accuracy and endurance of dermatologists in melanoma diagnosis

In a two-phase study, 76 dermatologists each assessed 16 images (melanomas and benign moles, known as nevi) taken with a dermatoscope, an illuminated magnifying glass, first using standard AI and then with an explainable AI solution. Explainable AI, or XAI for short, combines AI predictions with textual and image-based explanations based on established dermatoscopic features. Eye-tracking measurements were used to record how long and how intensi…Artificial Intelligence · Heidelberg Read Article

Clonal Tracing with Somatic Epimutations Reveals Dynamics of Blood Ageing

60% Left coverage: 5 sources

Current approaches used to track stem cell clones through differentiation require genetic engineering1,2 or rely on sparse somatic DNA variants3,4, which limits their wide application. Here we discover that DNA methylation of a subset of CpG sites reflects cellular differentiation, whereas another subset undergoes stochastic epimutations and can serve as digital barcodes of clonal identity. We demonstrate that targeted single-cell profiling of D…Nature · Barcelona See the Story

How the Epstein-Barr virus promotes its spread in the body

The Epstein-Barr virus, which belongs to the herpes virus family, was the first virus to be proven carcinogenic in humans. That was in the 1960s, and to this day it is not entirely clear how exactly the cancer-causing effect comes about. Interactions between EBV and the host organism's immune system are likely to be decisive, as only a small percentage of those infected develop cancers such as the highly aggressive Burkitt's lymphoma or stomach …Heidelberg, Germany · Heidelberg Read Article

Childhood brain tumors develop early in highly specialized nerve cells

100% Center coverage: 1 sources

Medulloblastomas, brain tumors in children, are thought to develop between the first trimester of pregnancy and the end of the first year of life. Researchers have now analyzed the genetic changes of each individual cancer cell in tumor samples in order to reconstruct which genetic changes occur first during tumor development and when.Medical · Heidelberg See the Story

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