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Nature · BarcelonaCurrent approaches used to track stem cell clones through differentiation require genetic engineering1,2 or rely on sparse somatic DNA variants3,4, which limits their wide application. Here we discover that DNA methylation of a subset of CpG sites reflects cellular differentiation, whereas another subset undergoes stochastic epimutations and can serve as digital barcodes of clonal identity. We demonstrate that targeted single-cell profiling of D…See the Story
Clonal Tracing with Somatic Epimutations Reveals Dynamics of Blood Ageing
60% Left coverage: 5 sources
Heidelberg, Germany · HeidelbergThe Epstein-Barr virus, which belongs to the herpes virus family, was the first virus to be proven carcinogenic in humans. That was in the 1960s, and to this day it is not entirely clear how exactly the cancer-causing effect comes about. Interactions between EBV and the host organism's immune system are likely to be decisive, as only a small percentage of those infected develop cancers such as the highly aggressive Burkitt's lymphoma or stomach …Read Article
