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ZMAT3 alleviates cell death in Fanconi anemia via adaptation of sphingolipid metabolism
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ZMAT3 alleviates cell death in Fanconi anemia via adaptation of sphingolipid metabolism
Abstract Fanconi anemia (FA) is characterized by defective DNA repair and chronic p53 activation, predisposing to acute myeloid leukemia through persistent genomic instability. The molecular adaptations enabling cell survival under chronic stress remain poorly understood. This study investigates the role of ZMAT3, a p53 responsive RNA binding protein overexpressed in FA deficient cells, to elucidate its role in cellular adaptation. Using FA pati…
·Washington, United States
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