Zebrafish study links altered neuronal genes to hyperarousal states
3 Articles
3 Articles
Zebrafish study links altered neuronal genes to hyperarousal states
The altered presence of tiny fragments of neuronal genes, called microexons, causes hyperarousal in zebrafish. This is the main conclusion of an international study led by the Pompeu Fabra University (UPF) and the Centre for Genomic Regulation (CRG).
Neuronal microexons modulate arousal via the cAMP-PKA-CREB pathway in zebrafish
Abstract Proper regulation of arousal maintains the balance of rest and activity and enables appropriate responses to stimuli; its disruption is a hallmark of many neurodevelopmental disorders. Although transcriptional mechanisms of arousal control are well defined, the contribution of posttranscriptional processes such as alternative splicing remains unclear. Here, we identify a critical role for the microexon splicing regulator srrm3 in mainta…
Barcelona, Spain. One study points out that the alteration of short fragments of neuronal genes -microexons- in zebra fish causes cerebral overactivation and insomnia, which shows that they are key to indicate to the brain when to rest. UPF and CRG identify the impact of microexons on sleep The research, carried out by Universitat Pompeu Fabra (UPF) and the Centre for Genomic Regulation (CRG), in Spain, and published in Science Advances, opens t…
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